Neath Port Talbot Council say the B4287 – Efail Fach, Pontrhydyfen – will close from “early” that day, possibly until 2pm.
Officers say essential maintenance is being carried out to provide a better surface.
Work is also scheduled to take place on the B4286 – Ty’r Owen Row, Cwmavon – this Sunday and next Sunday (February 17). The council aims to have the road open between those dates.
A council spokesman said: “We apologise for any inconvenience and thank road users for their cooperation and understanding.”
He added that they wished to minimise disruption for motorists and the local community.